Backpack®
Backpack Bone Graft Fusion System
for Spinal Procedures
AF
Osteoinductive Bone Graft
Allocell® AF utilizes a proprietary process that provides consistent hydration, moldability, osteoconductivity and osteoinductive potential.
AMP
Surface Activated Bone Graft
Our proprietary surface activated granules are comprised of scientifically and clinically studied biomaterials.
Backpack® is an advanced porous biologic scaffold designed to support optimal bone healing in spinal and orthopedic fusion procedures. This suite of products combine biologic activity with controlled containment for efficient, reproducible outcomes.
Efficient Delivery& Handling
Our pouch containment system is used as a carrier for bone graft materials, making it easy to deliver graft to the surgical site. This eliminates the need for mixing and packing particulate grafts, reducing procedure time and minimizing the risk of graft washout during placement.
Graft Containment at the Fusion Site
The porous type I collagen scaffold stablizes the graft at the fusion site while facilitating blood flow to the graft and allowing immediate integration with the host bone. This is critical for initiating bone formation and promoting early angiogenesis, both of which are essential for successful bone regeneration.
Biocompatible & Safe
Bovine tendon collagen is highly homologous to human collagen, resulting in minimal immune response and making it a safe material for clinical use in bone tissue engineering.
Integration
The collagen pouch is resorbable, meaning it is gradually replaced by the patient’s own bone during the remodeling process, leaving no residual foreign material. Each pouch is designed to integrate in as little as 30 days.
Cellular Flow
The collagen pouch is resorbable, meaning it is gradually replaced by the patient’s own bone during the remodeling process, leaving no residual foreign material. Each pouch is designed to integrate in as little as 30 days.
Sizes
You Decide What's Inside
AF
Osteoinductive Bone Graft
Allocell® AF utilizes a proprietary process that provides consistent hydration, moldability, osteoconductivity and osteoinductive potential.
Allocell® AF is a second-generation allograft with proprietary wide and elongated inductive fibers interconnected in a weave that provides more continuous surface area for cellular attachment and proliferation.
Hydrates instantly, retaining seven times its weight in physiological fluids. Allocell undergoes OI potential testing, which is the gold standard for ensuring efficacy and is sterilized via low-dose electron beam irradiation to achieve a sterility assurance level of 10-6.
AMP
Surface Activated Bone Graft
Our proprietary surface activated granules are comprised of scientifically and clinically studied biomaterials.
The base biphasic granules have a well established clinical history in spine fusion procedures and demonstrated equivalency to autograft in peer-reviewed clinical trials.
These submicron needle-shaped features on the surface of the granules create a microenvironment that can polarize macrophages to the M2 phenotype.
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Backpack Product FAQ
What is Backpack® AF osteoinductive bone graft made of?
Backpack® AF is an advanced porous biologic scaffold composed of Allocell® AF demineralized human cortical bone fibers enclosed within a perforated type I bovine collagen pouch. The Allocell® AF fibers are a second-generation allograft featuring proprietary wide and elongated inductive fibers interconnected in a weave, which provides continuous surface area for cellular attachment and proliferation.
What is the Backpack® pouch made of?
The Backpack® pouch is made from purified type I bovine collagen derived from the Achilles tendon. Bovine tendon collagen is highly homologous to human collagen, which minimizes immune response and makes it a safe material for clinical use in bone tissue engineering.
Does Backpack® AF come pre-loaded?
Yes. Backpack® AF is supplied preloaded with Allocell® AF fibers inside the perforated type I collagen pouch. This design eliminates the need for mixing or packing particulate graft in the operating room, thereby reducing procedure time and minimizing the risk of graft washout during placement.
How is Backpack® AF used in medical applications?
Backpack® AF is used in spinal and orthopedic fusion procedures where a biologic containment system supports native bone ingrowth. The pouch acts as a carrier that delivers the graft precisely to the surgical site, eliminating the need to mix or pack particulate graft.
Where is Backpack® AF used?
Backpack® AF is used in spinal fusion procedures. Its design as an advanced porous biologic scaffold with osteoinductive potential also supports orthopedic fusion applications where a contained, resorbable graft is preferred.
How is Backpack® AF prepared for use?
The Allocell® AF fibers inside Backpack® AF are processed through a proprietary process that provides consistent hydration, moldability, osteoconductivity, and osteoinductive potential. The final product is sterilized via low-dose electron-beam irradiation to achieve a sterility assurance level of 10-6, and Allocell undergoes OI potential testing, the gold standard for ensuring efficacy.
How many pouches does Backpack® AF come with?
Each Backpack® AF package currently contains two pouches. Ventris is working on a single-pouch box option in the future.
How many cc's does Backpack® AF come with?
Each Backpack® AF pouch contains 6.3 cc of graft material. The Medium package (two pouches) totals 12.6 cc, and the Large package (two pouches) totals 25.2 cc.
What are the sizes Backpack® AF is available in?
Backpack® AF is available in two sizes: Medium, measuring 18 x 50 x 7 mm, and Large, measuring 18 x 100 x 7 mm.
How is Backpack® AF hydrated?
Backpack® AF can be hydrated with blood, saline, bone marrow aspirate, or bone marrow concentrate at the surgeon’s discretion. The Allocell® AF fibers inside the pouch hydrate instantly, retaining up to 7 times their weight in physiological fluids, which gives the graft consistent handling characteristics regardless of the fluid used.
What is Backpack® AMP surface activated bone graft made of?
Backpack® AMP is composed of Ventris’ proprietary surface-activated biphasic ceramic granules contained within a perforated type I bovine collagen pouch. The surface topography process creates submicron, needle-shaped features on each granule that increase surface area for bone formation and produce a microenvironment that polarizes macrophages toward the M2 phenotype.
What is the Backpack® AMP pouch made of?
The Backpack® AMP pouch is made from purified type I bovine collagen derived from the Achilles tendon. Bovine tendon collagen is highly homologous to human collagen, thereby minimizing the immune response and making it a safe material for clinical use in bone tissue engineering.
Does Backpack® AMP come pre-loaded?
Yes. Backpack® AMP is supplied preloaded with surface-activated biphasic ceramic granules within the perforated type I collagen pouch. This design eliminates the need to mix or pack particulate graft in the operating room, thereby reducing procedure time and minimizing the risk of graft washout during placement.
How is Backpack® AMP used in medical applications?
After hydration, Backpack® AMP is used for fusion procedures of the posterolateral spine and the intervertebral disc space. The pouch serves as a carrier, delivering the surface-activated biphasic granules precisely to the surgical site while stabilizing the graft and facilitating blood flow, both of which support early bone formation and integration with host bone.
Where is Backpack® AMP used?
Backpack® AMP is used in spinal fusion procedures, including posterolateral spine and intervertebral disc space applications. Its fully synthetic composition also supports orthopedic fusion cases in which a synthetic bone graft is preferred over an allograft.
How is Backpack® AMP packaged and prepared?
Backpack® AMP is provided in a ported pouch that allows for the attachment of a hydration syringe prior to implantation. This design lets the surgeon deliver hydration fluid directly into the pouch and integrate it with the granules before placement at the fusion site, without opening the pouch or handling the graft loose.
What is the difference between Backpack® AMP and Backpack® AF?
Backpack® AMP is the fully synthetic option in the Backpack® system. It uses Ventris’ proprietary surface-activated biphasic ceramic granules and the patented surface topography process, rather than the demineralized human cortical bone fibers used in Backpack® AF. Both variants share the same porous Type I bovine collagen pouch and delivery design, allowing surgeons to choose between an allograft and a synthetic option based on procedural preference.
How many cc's does Backpack® AMP come with?
Each Backpack® AMP pouch contains 6.3 cc of graft material. The Medium package (two pouches) totals 12.6 cc, and the Large package (two pouches) totals 25.2 cc.
What are the sizes Backpack® AMP is available in?
Backpack® AMP is available in two sizes: Medium, measuring 18 x 50 x 7 mm, and Large, measuring 18 x 100 x 7 mm.
