Amplify Standalone Synthetic Bone Graft
Amplify® is a proprietary surface-activated bone graft comprised of scientifically and clinically studied biomaterials.
Amplify® comprises a proprietary mixture of biphasic (HA/βTCP) ceramic granules suspended in an alkylene oxide polymer carrier. The polymer carrier provides a cohesive matrix between granules that allows intra-operative molding by the surgeon and facilitates delivery to the surgical site. Amplify® can be used either standalone or in combination with autograft bone (1:1 ratio) as a bone graft extender. Amplify® is supplied in an open-barrel syringe, packaged in a blister pack that is terminally sterilized. The device is offered in sizes of X-Small (1.875 g), Small (3.75 g), Medium (7.50 g) and Large (15.0 g).
Equivalent to Autograft. Bimodal Resorption. Proprietary Surface Architecture.
Clinically Proven Performance
Demonstrated equivalency to autograft in prospective clinical trials, Amplify combines a bimodal resorption profile that nourishes healing in its earliest stages with sustained support for fusion maturation through late-stage remodeling.
Enhanced Cellular Integration
Increased surface area, porosity, and dissolution rate promote cellular attachment, proliferation, and remodeling.
Immune-Modulating
Polarizes macrophages toward the M2 phenotype.
Osteoinductive
Demonstrated in a large animal sheep model.
We enhance these granules utilizing our patented surface topography process.
These submicron needle-shaped features significantly increase surface area for bone formation and create a microenvironment that can polarize macrophages to the M2 phenotype.
Clinically Proven Biphasic Granules
The base biphasic granules used in Amplify have a well-established clinical history in spine fusion procedures and have demonstrated equivalency to autograft in peer-reviewed clinical trials.[1–4]
Cervical Fusion
Deformity Correction
Lumbar Fusion
Deformity Correction
Proprietary
Polymer Carrier
Cohesive Molecular Composition
Facilitates accurate graft placement and containment at the defect site and can be readily mixed with autograft bone.
Biologically Quiet Resorption
Resorbs into surrounding tissues and is excreted from the body within 24 hours of resorption. [7,8]
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What is Amplify® surface activated bone graft putty made of?
Amplify® is made of biphasic ceramic granules enhanced through Ventris’ patented surface topography process. The result is a resorbable, surface-activated synthetic bone graft designed to support bone formation at the fusion site.
How is Amplify® used In medical applications?
Amplify® can be used standalone or combined with autograft bone at a 1:1 ratio as a bone graft extender. It is placed in either the posterolateral spine or the intervertebral disc space during spinal fusion procedures.
Where is Amplify® used?
Amplify® is used in spinal fusion procedures. The base biphasic granules have a documented clinical history across cervical fusion, lumbar fusion, and deformity correction (scoliosis.)
How is Amplify® packaged and prepared?
Amplify® is supplied in an open-barrel syringe, sealed inside a blister pack that is terminally sterilized in its final packaging. The open-barrel design lets the surgeon deliver the product directly into the graft site without a separate delivery device, which reduces prep time and minimizes items opened on the sterile field
What are the sizes Amplify® is available in?
X-Small, Small, Medium, and Large.
